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Post-Traumatic Epilepsy

With the help of a $10 million grant from the U.S. Department of Defense, CURE is creating a new, first-of-its-kind research program and focus on post-traumatic epilepsy (PTE) as a result of traumatic brain injury (TBI).

About the Initiative

This unprecedented, multi-disciplinary program will devote significant resources over five years toward research which will benefit veterans who have been affected by TBI and resulting PTE. The goal of CURE’s new initiative is to establish a multi-center, multi-investigator research team that will rapidly translate patient-relevant findings at the molecular, cellular, and systems level into novel therapies to prevent the development of epilepsy from TBI. This ‘team science’ model will establish a foundation of knowledge regarding what types of injury increase risk to development of epilepsy and how it is best studied in the laboratory.

The key aims of the program are for thought leaders in the field to address questions with a peer-reviewed approach. An External Advisory Council also provides scientific and logistical oversight over the selected investigative team. As science drives the initiative, additional funds will be awarded to further the understanding of PTE.


"We are committed to exploring the complex underlying mechanisms of post-traumatic epilepsy...and one day, being able to prevent it entirely." 


Related Research

Modulation of Toll-Like Receptors to Prevent Post-traumatic Epileptogenesis
Vijayalakshmi Santhakumar, PhD
New Jersey Medical School
Glia Activation and Vascular Changes as Biomarkers of Epileptogenesis: MRI/MRS Longitudina...
Teresa Ravizza, PhD
Mario Negri Institute for Pharmacological Research
Network and Axonal Mechanisms Underlying the Transition to Post-Traumatic Epilepsy Followi...
John Wolf, PhD
University of Pennsylvania

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